Migraines Headache | The Best Treatment of It

CBD oil may be an option for pain relief. Authors of a study from 2012 suggest that CBD oil can help to relieve some types of chronic pain. However, the study did not relate specifically to headaches or migraines. Results of a 2016 study indicate that medical marijuana may reduce the frequency of migraine headaches

Severe headaches are exhausting to endure and lasts long from 5 to 72 hours. By this time, the treatment of headaches and migraines have been painkillers including, Triptans, paracetamol, or ibuprofen.

Although painkillers help in alleviating the symptoms of migraines by blocking the pain pathways and constricting the blood vessels, due to their side effects people want some other ways of getting rid of severe migraines. This reason is where CBD oil makes its way to the top of the list.

Although research on CBD oil is insufficient, recent studies portrayed that migraines may occur due to the deficiency of endocannabinoids and odd inflammatory response.

Also, many laboratory studies proved that CBD oil could efficiently treat all acute and chronic migraines. CBD oil has been showing some significant benefits for an extensive range of medical conditions most importantly migraines.

 

CBD Oil for Treating Migraines – How It Works?

Inside our body and brain, there are different cannabinoid receptors (CB1, CB2, WIN and anandamide receptor).

These Cannabinoid receptors consist of intra-and extracellular loops, and seven folded transmembrane helices that affect pain signals.

To activate the Cannabinoid receptors for modulating neural transmission, endocannabinoids, or endogenous cannabinoids play a vital role.

These different endocannabinoids are present in lesser amounts in the tissues and brain and actively participate to regulate various cerebral functions such as mood, pain, perception, appetite, and memory.

The dysfunction or lower level of endocannabinoids leads to migraine headaches. The deficiency of endocannabinoids can be addressed by introducing the cannabinoids in the body.

CBD inhibits the uptake and enzymatic degradation of anandamide via FAAH and regulates many metabolic pathways, elevating anandamide extracellular concentrations.

By maintaining the higher level of anandamide in the body would potentially reduce the feelings of the pain.

Cannabinoids usually bind to the periaqueductal gray matter that modulates pain transmission. The area of the brain associated with severe headaches consists of higher levels of the endocannabinoid receptor CB1.

Also, CBD helps in preventing the metabolism of anandamide that ultimately reduces the regulation of pain. Being an anti-inflammatory compound, it reduces pain in the body and diminishes other immune-system responses.

CBD oil is available in various forms including, vape oils, capsules, and drops. Patients using CBD oils showed improvement in their rate of migraine attacks. Reported by the community members, CBD oil available in drops is the most popular form for personal use.

CBD oil for migraines is available in multiple forms. Most effective forms are ingestion or vaping. One of the most effective and simplest ways of using it is the sublingual method.

The sublingual method requires placing a few drops of CBD oil beneath your tongue, and then it diffuses through the thin membrane and moves to the place where it is needed and shows beneficial effects.

Also, it causes almost no side-effects. You can even eat a CBD infused treat or tablets of CBD oil. If you are at home and you don’t have to go anywhere, and you are suffering from a severe migraine, then you can use the vaping method of CBD oil.

The CBD oil vaping method can be very useful in treating migraines because  the inhaling process or vaping transport the compounds directly into the bloodstream much rapidly than any other method.

REFERENCES

  1. Akerman, S., Holland, P.R., Lasalandra, M.P. and Goadsby, P.J. (2013, September). Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and “triptan” receptors: implications in migraine. Journal of Neuroscience, 33(37), 14869-77. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771033/.
  2. Greco, R., Gasperi, V., Maccarrone, M., and Tassorelli, C. (2010, July). The endocannabinoid system and migraine. Experimental Neurology, 224(1), 85-91. Retrieved from http://www.sciencedirect.com/science/article/pii/S0014488610001159.
  3. Greco, R., Mangione, A.S., Sandrini, G., Nappi, G. and Tassorelli, C. (2014, March). Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model. The Journal of Headache and Pain, 15, 14. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995520/.
  4. Greco, R., Mangione, A.S., Sandrini, G., Maccarrone, M., Nappi, G. and Tassorelli, C. (2011). Effects of anandamide in migraine: data from an animal model. The Journal of Headache and Pain, 12(2), 177-83. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072518/.
  5. McGeeney, B.E. (2013). Cannabinoids and hallucinogens for headache. Headache, 53(3), 447-58. Retrieved from http://onlinelibrary.wiley.com/wol1/doi/10.1111/head.12025/full.
  6. Migraine (2013, June 4). Mayo Clinic. Retrieved from http://www.mayoclinic.org/diseases-conditions/migraine-headache/basics/definition/con-20026358.
  7. NINDS Migraine Information Page. (n.d.) National Institute of Neurological Disorders and Stroke. Retrieved from http://www.ninds.nih.gov/disorders/migraine/migraine.htm.
  8. Rhyne, D.N., Anderson, S.L., Gedde, M., and Borgelt, L.M. (2016, January 9). Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population. Pharmacotherapy, doi: 10.1002/phar.1673. Retrieved from http://onlinelibrary.wiley.com/wol1/doi/10.1002/phar.1673/full.
  9. Russo, E.B. (1998, May). Cannabis for migraine treatment: the once and future prescription? An historical and scientific review. Pain, 76(1-2), 3-8. Retrieved from http://journals.lww.com/pain/pages/articleviewer.aspx?year=1998&issue=05000&article=00002&type=abstract.
  10. Russo, E.B. (2001). Hemp for Headache: An In-Depth Historical and Scientific Review of Cannabis in Migraine Treatment. Journal of Cannabis Therapeutics, 1(2), Retrieved from http://www.tandfonline.com/doi/abs/10.1300/J175v01n02_04.
  11. Wilsey, B., Marcotte, T., Deutsch, R., Gouaux, B., Sakai, S., and Donaghe, H. (2013, February). Low-dose vaporized cannabis significantly improves neuropathic pain. The Journal of Pain, 14(2), 136-48. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566631/.

 

Disclaimer : This website contains general information about cbd oil and the possible health benefits. The information is not advice and is not a substitute for advice from a healthcare professional. You must not rely on the information  as an alternative to medical advice from your doctor or other professional healthcare providers. FDA Disclosure:CBD products are not approved by the FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease. While we publish and refer to currently available research on cannabidiol, terpenoids and other properties of hemp-derived cannabis oils, it is important to note: None of the products or information available on this website are intended to be a treatment protocol for any disease state. The information presented is for educational purposes only and should not be construed as medical advice or instruction.  The FDA would want us to remind you: You should always seek the advice of a physician before adding any supplements to your diet.

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